I've never historically eaten any foods with Splenda in them, but perhaps other artificial sweeteners have a similar effect on the gut.
An excerpt:
The theory that Splenda may be a culprit in the rise of inflammatory bowel disease (IBD) appears to be a reasonable one, echoing the results from a 2008 study published in the Journal of Toxicology and Environmental Health, which discovered that Splenda:
- Increases the pH level in your intestines, and
- Reduces the amount of good bacteria in your intestines by 50 percent!